Kev Sib Koom|Cov txheej txheem sau tshuaj tiv thaiv yooj yim thiab ua tau zoo
CaseSharib | Simple thiabEtxausVaccineCollectionProcess
Kab mob kis kab mob yog ib hom kab mob uas ua rau mob hnyav rau kev noj qab haus huv ntawm cov tsiaj qaib. Tam sim no, tshuaj tua kab mob yog cov tshuaj tseem ceeb siv hauv kev kho mob ntawm cov kab mob sib kis. Txawm li cas los xij, kev tsim txom ntawm cov tshuaj tua kab mob ua rau muaj cov kab mob tshuaj tiv thaiv sai heev, tshwj xeeb tshaj yog cov kab mob ntau yam tshuaj tiv thaiv kab mob, uas tsis tuaj yeem tswj tau tus kab mob zoo, dhau los ua teeb meem nyuaj hauv kev kho mob thiab nqa lub nra hnyav rau lub neej.
Cov tshuaj tiv thaiv kab mob tuaj yeem txhim kho qhov kev tiv thaiv ntawm cov tsiaj raug mob rau cov kab mob pathogenic, txo qhov tshwm sim ntawm cov kab mob pathogenic, thiab muaj txiaj ntsig zoo rau kev tswj cov kab mob sib kis. Yog li ntawd, txoj kev loj hlob ntawm cov tshuaj tiv thaiv kab mob muaj feem xyuam yog qhov kev tshawb fawb hotspot nyob rau hauv daim teb no.
Feem ntau, cov txheej txheem ntawm cov tshuaj tiv thaiv kab mob veterinary yog hom kab lis kev cai, fermentation, purification, configuration thiab filling, uas purification yog muab faib ua concentration, kua hloov, sau, thiab membrane filtration technology tau ncaj qha ua tiav peb cov txheej txheem nyob rau hauv ib lub sij hawm.
Tangential flow filtration technology yog ib qho siv dav siv cov tshuab ua kua membrane, thiab hollow fiber membrane yog ib qho tseem ceeb ntawm kev sib cais membrane. Nyob rau hauv chav tsev ntim membrane Cheebtsam, hollow fiber membrane muaj qhov loj tshaj plaws zoo membrane cheeb tsam, siab pom thiab sib cais efficiency, yooj yim los ntxuav, yooj yim qauv, yooj yim ua hauj lwm, thiab tsis muaj kuab paug nyob rau hauv cov txheej txheem ntau lawm, yog li nws yog dav siv.
Hauv qab no yog cov ntaub ntawv thov ntawm Guidling hollow fiber hauv thallus purification.
Thallus 1
Peb ntxuav 700mL ntawm thallus 1 nrog 94 cm² hollow fibers. Thaum lub sij hawm tag nrho cov kev sim, tus nqi rov qab thiab membrane flux depletion raug soj ntsuam.
0-73min yog cov txheej txheem concentration, 73-121min yog cov txheej txheem ua kua pauv, 121-149min yog cov txheej txheem "dhau" concentration. Thaum lub sij hawm tag nrho cov kev sim, TMP yog qhov ruaj khov, cov kua inlet ceev tsis hloov, thiab cov khoom nruab nrab flux yog 47LMH.
Cov kua 700mL tau concentrated thiab hloov mus rau 17mL, kwv yees li 41 npaug ntawm cov concentration, thiab cov kab mob concentration tau txiav txim siab yog 2.83 × 1010cfu / mL. Tag nrho cov kab mob yog 4.81 × 1011cfu, thiab tus nqi rov qab yog 70.1%. Tom qab ntxuav sab saum toj, nce 20mL kua, 1.68 × 1011cfu cov kab mob tag nrho, tom qab ntawd tag nrho rov qab yog 94.6%, kev tsim khoom lag luam raws li qhov tuag ntim ntawm cov kav xa dej suav, kom deb li deb tau nce tus naj npawb ntawm kev ntxuav sab saum toj, feem ntau 3 zaug tuaj yeem rov qab tau zoo.
Thallus 2
Peb lim 50mL ntawm thallus 2 nrog 94 cm² hollow fibers. Thaum lub sij hawm tag nrho cov kev sim, tus nqi rov qab thiab membrane flux depletion raug soj ntsuam.
0-7min yog cov txheej txheem concentration, 7-27min yog cov txheej txheem ua kua pauv, thiab 27-34min yog cov txheej txheem "dhau" concentration. Thaum lub sij hawm tag nrho cov kev sim, TMP yog qhov ruaj khov, cov kua inlet ceev tsis hloov, thiab cov khoom nruab nrab flux yog 64LMH.
Lub 50mL pub kua yog concentrated thiab hloov mus rau 20mL, thiab cov kab mob concentration tau txiav txim siab 2.8 × 108cfu / mL. Tag nrho cov kab mob yog 5.6 × 109cfu, thiab tus nqi rov qab yog 80%. Tom qab ntxuav sab saum toj, nce 20mL kua, 1.12 × 109cfu cov kab mob tag nrho, tom qab ntawd tag nrho rov qab yog 96%, kev tsim khoom lag luam raws li qhov ntim tuag ntawm cov raj xa dej, kom deb li deb tau los ua kom tus naj npawb ntawm kev ntxuav sab saum toj, sab saum toj ntxuav. 3 zaug tuaj yeem rov qab tau zoo.
Tangential flow filtration ntawm cov kab mob los ntawm microfiltration los yog ultrafiltration yog ib qho tseem ceeb ntawm daim nyias nyias nyias. Piv nrog rau cov tsoos lim phaj Z ncuav mog qab zib pom thiab diatomite pom, txoj kev tangential flow filtration tuaj yeem ua tiav cov txiaj ntsig siab, siab yield, haum rau kev lag luam loj loj, thiab yooj yim rau kev ua haujlwm aseptic.
Lub hollow fiber ntawm Guidling thev naus laus zis tuaj yeem tsis tsuas yog ua tau raws li qhov xav tau ntawm thallus purification, tab sis kuj ua tau raws li qhov xav tau ntawm kev tshem tawm pyrogen, thiab qhov kev rov zoo ntawm thallus tuaj yeem ncav cuag ntau dua 95%.
Guidling thev naus laus zis zoo siab tos txais koj los thov kev teeb tsa kev sim los ua qhov kev ntsuas cuam tshuam!
Hais txog Guidling
Guidling Technology yog lub teb chaws high-tech enterprise tsom rau biopharmaceuticals, cell culture, purification thiab concentration ntawm biomedicine, kuaj mob thiab muaj kua. Peb tau ua tiav cov khoom siv lim dej centrifugal, ultrafiltration & microfiltration cassettes, cov kab mob lim, TFF system, qhov tob lim, hollow fiber, thiab lwm yam. Uas tau raws li daim ntawv thov scenarios ntawm biopharmaceuticals, kab lis kev cai ntawm tes, thiab lwm yam. Peb cov membranes thiab cov lim dej lim tau dav siv hauv kev sib xyaw, kev rho tawm thiab kev sib cais ntawm kev pom ua ntej, microfiltration, ultrafiltration thiab nanofiltration. Peb cov kab ntau cov khoom, los ntawm me me, ib leeg-siv kuaj pom mus rau ntau lawm filtration systems, sterility kuaj, fermentation, cell kab lis kev cai thiab lwm yam, ua tau raws li cov kev xav tau ntawm kev sim thiab ntau lawm. Guidling Technology tab tom tos ntsoov rau kev koom tes nrog koj!
