Daim Ntawv Thov Ntawm Ultrafiltration Hauv Kev Cuam Tshuam Thiab Purification Ntawm Avian Influenza Vaccine

Daim ntawv thov ntawmUltrafiltration nyob rau hauv cov ntaub ntawvConcentration thiabPurification ntawmAvianInfluenzaVaccine

Avian influenza yog ib yam kab mob sib kis ntawm cov noog uas tshwm sim los ntawm tus kab mob khaub thuas A uas muaj cov tsos mob xws li ua pa mus rau qhov mob hnyav heev. Avian influenza yog kis tau yooj yim ntawm cov noog thiab siv los ua lub npe hu ua "fowl plague", uas tau muab cais ua ib hom kab mob sib kis los ntawm OIE.

Cov kab mob khaub thuas avian tau tshwm sim hauv Australia, Ltalis, Hong Kong, Tuam Tshoj, thiab Netherlands raws li hauv 1994, 1997, 1999, thiab 2003, thiab feem ntau nyob rau sab hnub tuaj Asia thiab Europe hauv xyoo 2005. Lub xyoo 2022 tus kab mob khaub thuas avian tau tshwm sim los ntawm 47 tus neeg ua liaj ua teb. Tebchaws Asmeskas tau poob tag nrho ze li 59 lab tus nqaij qaib, suav nrog cov nteg qe, qaib ntxhw, thiab nqaij qaib, nrog tsoomfwv poob nyiaj ntau tshaj $ 660 lab, ua rau nws yog tus kab mob khaub thuas ua npaws tshaj plaws nyob rau hauv keeb kwm ntawm Teb Chaws Asmeskas Daim ntawv tshaj tawm tshiab los ntawm Lub Kaum Hli 25, 2023, tau qhia tias cov xwm txheej ntawm HPAI tau tshwm sim thaum Lub Kaum Hli hauv ntau lub xeev Asmeskas, nrog rau tag nrho cov nqaij qaib kis tau ntau tshaj 600,000, ntawm uas ntau dua 290,{14}} yuav tsum tau txiav tawm kom tsis txhob kis tus kab mob. kab mob.

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AvianInfluenzaVaccine

Txoj kev tshawb fawb tseem ceeb ntawm daim ntawv thov ntawm ultrafiltration nyob rau hauv cov concentration thiab purification ntawm avian influenza H9N2 tshuaj tiv thaiv yuav raug nthuav tawm ntawm no.

Avian influenza H9N2 yog ib hom kab mob uas tsis tshua muaj kab mob uas muaj nyob hauv tsev neeg Orthomyxoviridae. Cov subtype no muaj nyob rau hauv kev lag luam nqaij qaib raws li qhov kis tau tus mob, yog li tau muaj kev txaus siab tshwj xeeb hauv kev tsim cov tshuaj tiv thaiv kab mob khaub thuas H9N2. Cov tshuaj tiv thaiv kab mob khaub thuas H9N2 yog tsim los ntawm kev tua tus kab mob thiab siv cov tshuaj tiv thaiv kab mob tsis muaj zog thiab cov roj theem. Cov txheej txheem qe-raws li tam sim no yog siv los npaj cov tshuaj tiv thaiv kab mob khaub thuas avian inactivated. Cov tshuaj tiv thaiv kab mob ntawm cov qe muaj ntau cov proteins uas tsis xav tau uas yuav cuam tshuam rau kev tsim tshuaj tiv thaiv. Tsis tas li ntawd, kev tsim cov tshuaj tiv thaiv ua ke ntawm cov koob tshuaj tsawg yuav tsum tau nce cov tshuaj tiv thaiv antigen. Qhov no qhia txog qhov yuav tsum tau ua kom muaj antigen concentration los ntawm kev txhim kho downstream purification p

rocesses.

Tom qab sau thiab qhia meej cov kab mob uas muaj allantoic kua, nws tau concentrated thiab purified nrog ultrafiltration txoj kev. Cov tshuaj nquag thiab purified kuaj tau soj ntsuam rau qib ovalbumin.

Raws li tuaj yeem pom los ntawm SDS-PAGE electropherogram, qhov concentration thiab purification tuaj yeem tshem tawm cov heteroprotein zoo.

Kev tshuaj xyuas ntawm HI titers hauv cov qaib uas tau txhaj tshuaj tiv thaiv cov tshuaj tiv thaiv kab mob siab tshaj plaws tau pom tias lub cev tiv thaiv kab mob siab tshaj qhov txwv (HI=5) rau 4 lub hlis tom qab txhaj tshuaj tiv thaiv thiab peaked tsuas yog hnub 99 tom qab txhaj tshuaj tiv thaiv ib zaug. Raws li tus qauv ntawm kev txhaj tshuaj ntev ntev, cov tshuaj tiv thaiv kab mob yuav txaus los npog qhov txwv tsis pub dhau 6 lub hlis.

Cov tshuaj tiv thaiv muaj zog thiab ua kom huv si tau zoo hauv kev txhim kho lub cev tiv thaiv kab mob ntawm cov menyuam qaib nyob rau lub sijhawm ntev. Raws li cov txiaj ntsig saum toj no, kev siv thev naus laus zis ultrafiltration tuaj yeem txiav txim siab txhawm rau txhim kho cov txheej txheem qis qis (kev ua kom zoo thiab ua kom huv) ntawm cov tshuaj tiv thaiv kab mob khaub thuas (H9N2) txhawm rau npaj cov tshuaj tiv thaiv kom ruaj khov ntawm qhov loj yam tsis muaj kev pheej hmoo txaus ntshai.

Guidling Technology's ultrafiltration membrane cassettes tau siv dav hauv R & D thiab tsim cov kab mob khaub thuas kis thoob ntiaj teb thiab cov tshuaj tiv thaiv, nrog cov nqi rov qab thiab fluxes ze rau cov neeg txawv teb chaws, thiab cov kws qhia kev lag luam zoo siab tos txais los soj ntsuam.

Guidling Technology yog lub teb chaws high-tech enterprise tsom rau biopharmaceuticals, cell culture, purification thiab concentration ntawm biomedicine, kuaj mob thiab muaj kua. Peb tau ua tiav cov khoom siv lim dej centrifugal, ultrafiltration & microfiltration cassettes, cov kab mob lim, TFF system, qhov tob lim, hollow fiber, thiab lwm yam. Uas tau raws li daim ntawv thov scenarios ntawm biopharmaceuticals, kab lis kev cai ntawm tes, thiab lwm yam. Peb cov membranes thiab cov lim dej lim tau dav siv hauv kev sib xyaw, kev rho tawm thiab kev sib cais ntawm kev pom ua ntej, microfiltration, ultrafiltration thiab nanofiltration. Peb cov kab ntau cov khoom, los ntawm me me, ib leeg-siv kuaj pom mus rau ntau lawm filtration systems, sterility kuaj, fermentation, cell kab lis kev cai thiab lwm yam, ua tau raws li cov kev xav tau ntawm kev sim thiab ntau lawm. Guidling Technology tab tom tos ntsoov rau kev koom tes nrog koj!