Cov Txheej Txheem Luv Ncauj Los Ntawm Cov Tshuaj Tiv Thaiv Kab Mob Taw thiab Qhov Ncauj
Cov kab mob ko taw thiab qhov ncauj (FMD) yog ib qho mob hnyav, kub thiab kis tau zoo heev los ntawm tus kab mob ko taw thiab qhov ncauj, uas tuaj yeem kis tau yuav luag txhua tus tsiaj cloven-hoofed ( npua, nyuj thiab yaj, thiab lwm yam). Nws yog tus kab mob kis tau zoo tshaj plaws nyob rau tam sim no thiab muaj kev phom sij tshaj plaws rau tsiaj txhu.
Txoj hauv kev tseem ceeb ntawm kev kis tus kab mob ko taw thiab qhov ncauj yog lub plab zom mov thiab ua pa, ua rau daim tawv nqaij puas, mucous daim nyias nyias thiab daim tawv nqaij tsis zoo (xws li daim tawv nqaij ntawm lub mis), mucous membranes (qhov muag conjunctiva). Nws tuaj yeem kis tau los ntawm huab cua, nrog rau cov zis, mis nyuj, phev thiab qaub ncaug. Kev tiv thaiv thiab tswj cov kab mob ko taw thiab qhov ncauj hauv peb lub teb chaws feem ntau yog los ntawm kev txhaj tshuaj tiv thaiv, thiab kev kis tus kab mob ko taw thiab qhov ncauj yog tua. Kev txhaj tshuaj yog ib txoj hauv kev zoo ntawm kev tiv thaiv kab mob ko taw thiab qhov ncauj.
Kev txhaj tshuaj tiv thaiv yog ib txoj kev txhim khu kev qha thiab muaj txiaj ntsig zoo ntawm kev tiv thaiv kab mob ko taw thiab qhov ncauj, thiab tshuaj tiv thaiv zoo thiab siv tau zoo yog qhov yuav tsum tau ua ua ntej rau kev tiv thaiv, kev tswj hwm thiab kev tshem tawm ntawm cov kab mob ko taw thiab qhov ncauj thaum kawg. Cov tshuaj tiv thaiv kab mob qis thiab tsis muaj zog thiab lwm yam tshuaj tiv thaiv kab mob muaj cov tshuaj tiv thaiv kab mob zoo thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab tswj cov kab mob ko taw thiab qhov ncauj. Txawm li cas los xij, kev kis tus kab mob ko taw thiab qhov ncauj hauv qee qhov chaw hauv ntiaj teb zoo li muaj feem cuam tshuam nrog cov kab mob nyob hauv cov tshuaj tiv thaiv tsis muaj zog vim tsis muaj kev nyab xeeb xws li cov kab mob muaj zog, kev ua tsis tiav ntawm cov kab mob, thiab cov kab mob nyob hauv cov nroj tsuag ua haujlwm. Ua kom muaj kev tshawb nrhiav tshuaj tiv thaiv ko taw thiab qhov ncauj zoo dua thiab muaj txiaj ntsig zoo dua. Nrog rau txoj kev loj hlob sai ntawm molecular biology thev naus laus zis, cov kab mob ko taw thiab qhov ncauj (FMDV) cov tshuaj tiv thaiv kab mob caj ces, xws li tshuaj tiv thaiv subunit, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv peptide, tshuaj tiv thaiv kab mob protein, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob nucleic acid. , thiab lwm yam, tab tom tshwm sim.
Cov txheej txheem tsim cov tshuaj tiv thaiv kab mob ko taw thiab qhov ncauj tsis muaj zog
Kev tsim cov cuab yeej siv tshuaj tiv thaiv kab mob genetic engineering tshuaj tiv thaiv kab mob ko taw thiab qhov ncauj
Kev pom tseeb
Sib sib zog nqus filtration membrane: Lim tshuab yog dav siv nyob rau hauv cov txheej txheem ntawm cov khoom lom xws li tshuaj tiv thaiv, uas DC filtration technology feem ntau yog siv nyob rau hauv cov txheej txheem sau cov kab mob venom los cais insoluble impurities xws li cell debris. Nyob rau hauv FMDV thaum ntxov, qhov pom kev siv thev naus laus zis uas sawv cev los ntawm folding membrane lim caij tau txais yuav. Nrog rau kev hloov pauv ntawm kab lis kev cai, qhov nce ntawm cov khib nyiab ntawm tes tsis huv, qhov pom ntawm qhov chaw tsis yooj yim kom ua tiav cov txiaj ntsig kom pom tseeb, thiab vim tias cov khoom siv lim dej tsis zoo, tus nqi ntawm cov ntaub ntawv lim tau nce siab dua thiab siab dua.
Raws li cov keeb kwm yav dhau los, kev sib sib zog nqus pom tau siv ntau thiab ntau dua hauv cov txheej txheem ntawm kev sib cais ntawm cytoliquid ntawm FMDV, thiab yog ib txoj hauv kev siv ntau tshaj plaws rau kev sau qoob loo tam sim no. Qhov sib sib zog nqus lim membrane feem ntau yog tsim los ntawm cellulose, ntxeem tau lim AIDS (xws li lub ntiaj teb diatomaceous) thiab zoo ion lim AIDS, thiab cov channel tsim tom qab zaj duab xis yog feem ntau tortuous, zoo ib yam li labyrinth aperture qauv. Cov khoom impurity feem ntau yog daig hauv cov khoom lim dej ntau dua li ntawm qhov chaw, thiab cov phab ntsa ntawm cov lim dej feem ntau absorbs qee qhov tsis zoo ntawm cov impurities los ntawm electrostatic kev txiav txim los yog intermolecular quab yuam. Vim yog qhov sib ntxiv ntawm qee qhov lim AIDS, sib sib zog nqus pom kuj tuaj yeem tshem tawm qee qhov dej tsis huv, yog li txo qhov siab ntawm cov kauj ruam purification tom ntej.
Txawm li cas los xij, thaum qhov kev cog qoob loo loj dhau lawm, ntau qhov sib sib zog nqus lim membrane yuav tsum tau ua, ua rau muaj kev nce nqi ntawm cov khoom siv. Nyob rau tib lub sijhawm, qhov siab ceev ntawm cov kab lis kev cai ntawm tes yuav txo cov load ntawm cov lim dej sib sib zog nqus, ua rau cov nqi nce ntxiv thiab cov khoom siv ntau dhau.
Microfiltration Microfiltration method, siv lub ntsiab ntawm tangential flow filtration device, membrane Cheebtsam yog ca nyias nyias cassette thiab hollow fiber. Tangential flow filtration (TFF) yog tsav los ntawm qhov sib txawv ntawm qhov sib txawv ntawm transmembrane. Cov tshuaj thiab impurities me dua li daim nyias nyias pore loj dhau los ntawm daim nyias nyias, thaum impurities xws li cov hlwb uas muaj cov khoom loj dua raug kaw. Qhov pore loj ntawm daim nyias nyias siv rau microfiltration yog {{0}}.45/0.22μm. Hollow fiber ntau tangential flow microfiltration tuaj yeem ua cov txheej txheem siab cov ntsiab lus ua kua, xws li high-density cell kab lis kev cai nruab nrab, tuaj yeem tshem tawm cov centrifugation thiab pre-filtration cov kauj ruam, tsawg dua cov kauj ruam, kev ua haujlwm yooj yim, daim nyias nyias tuaj yeem siv rov qab los ntawm kev tu, txo cov cuab yeej siv thiab kev ua haujlwm. cov nqi, nyob rau hauv txoj kab nrog cov kev cai ntawm modular automated ntau lawm.
Ultrafiltration(Concentration hloov)
Ultrafiltration tuaj yeem tshem tawm qee qhov hnyav molecular ntawm lwm cov proteins thiab cov txheej txheem cuam tshuam nrog impurities, xws li inactivators, thiab txo cov ntim ntawm cov kua qoob loo, uas yog qhov zoo rau cov txheej txheem tom ntej. Ultrafiltration txoj kev, kev siv lub ntsiab ntawm tangential flow filtration device, cov khoom siv membrane muaj lub hnab ntawv membrane thiab hollow fiber ob, nyob rau hauv ib txwm muaj xwm txheej, daim ntawv thov ntawm ultrafiltration system tuaj yeem ua rau tus kab mob concentration ntau dua 100 zaug, kev tshem tawm ntawm lwm yam proteins mus txog. 99%. Ntawm lawv, hollow fiber membrane cov khoom muaj qhov zoo ntawm me me thiab qis shear quab yuam, tsis yooj yim rau ntsaws, hloov tau yooj yim, lub neej ntev thiab tus nqi qis, thiab yooj yim kom loj, yog li nws pom zoo kom xaiv cov hollow fiber ntau rau cov kab mob ntxiv thiab purification.
Thaum siv ultrafiltration txoj kev los mloog cov kua, nws yog ib qho tseem ceeb heev uas yuav tau xaiv ib tug haum membrane aperture, uas ncaj qha txiav txim siab efficiency ntawm concentration thiab cov khoom zoo. Ntawm qhov tod tes, nws yog ib qho tsim nyog yuav tau xaiv cov membrane aperture kom zoo cuab lub hom phiaj molecules kom ntseeg tau tias cov tawm los, thiab ntawm qhov tod tes, cov nyhuv tshem tawm thiab kev ua haujlwm ceev ntawm heteroproteins yuav tsum tau txiav txim siab tag nrho. Yog li ntawd, lub hauv paus ntsiab lus zoo tshaj plaws yog xaiv cov membrane nrog lub pore loj tshaj plaws uas tuaj yeem cuam tshuam lub hom phiaj molecule, thiab sim xaiv cov lim membrane nrog cov pore loj faib.
Rau cov tshuaj tiv thaiv FMD attenuated/inactivated, 100-750kd aperture ultrafiltration membrane feem ntau yog siv los ua kom tiav qhov cuam tshuam ntawm FMDV. Rau FMD cov tshuaj tiv thaiv kab mob genetic engineered, ib daim nyias nyias aperture 3-6 zaug (nyiam dua 5 zaug) ntawm qhov hnyav molecular ntawm lub hom phiaj yog feem ntau xaiv.
Kev taw qhiaTechnology
Hangzhou Guidling Technology Co., Ltd. yog lub chaw tsim khoom-taw qhia txog lub teb chaws high-tech enterprise tsom mus rau kev nthuav dav hauv qab, kev sib cais thiab kev ua kom huv ntawm biopharmaceuticals. Cov khoom siv dav siv hauv cov tshuaj tiv thaiv, cov tshuaj tiv thaiv monoclonal, kev kuaj mob, cov khoom siv ntshav, ntshav, endotoxin thiab lwm yam khoom siv tshuaj lom neeg pom cov txheej txheem; Peb muaj "flat membrane cassette", "hollow fiber kem", "Tangential flow filter device", "virus filter", "deep membrane stack", "bacteria filter" thiab lwm yam khoom; Peb muaj ntau yam khoom lag luam, los ntawm cov khoom siv pov tseg me me mus rau cov tshuab pom ntau lawm, kom ua tau raws li qhov xav tau ntawm kev sim thiab ntau lawm. Guidling Technology tab tom tos ntsoov rau kev koom tes nrog koj!